Immunopathology of Pulmonary Mycobacterium tuberculosis Infection in a Humanized Mouse Model.

ABSTRACT: Despite the availability of antibiotic therapy, tuberculosis (TB) is prevailing as a leading killer among human infectious diseases, which highlights the need for better intervention strategies to control TB. Several animal model systems, including mice, guinea pigs, rabbits, and non-human primates have been developed and explored to understand TB pathogenesis. Although each of these models contributes to our current understanding of host-Mycobacterium tuberculosis (Mtb) interactions, none of these models fully recapitulate the pathological spectrum of clinical TB seen in human patients. Recently, humanized mouse models are being developed to improvise the limitations associated with the standard mouse model of TB, including lack of necrotic caseation of granulomas, a pathological h

SUBMITTER: Kolloli A 

PROVIDER: S-EPMC10855034 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature