Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.

ABSTRACT: Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to the protracted timeline of prefrontal development, which likely does not reach full maturity before the end of adolescence. However, the underlying mechanisms that drive the emergence and fine-tuning of cognitive abilities during adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored prefrontal activity throughout the postnatal development of mice and showed that an initial activity increase was interrupted by an extensive microglia-mediated breakdown of activity, followed by the rewiring of circuit elements to achieve adult-like patterns and synchrony. Interfering with these processes during adolescence, but not ad

SUBMITTER: Popplau JA 

PROVIDER: S-EPMC10855252 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature