A Missense Variant in TP53 Could Be a Genetic Biomarker Associated with Bone Tissue Alterations.

ABSTRACT: Metabolic bone diseases cover a broad spectrum of disorders that share alterations in bone metabolism that lead to a defective skeleton, which is associated with increasing morbidity, disability, and mortality. There is a close connection between the etiology of metabolic bone diseases and genetic factors, with TP53 being one of the genes associated therewith. The single nucleotide polymorphism (SNP) Arg72Pro of TP53 is a genetic factor associated with several pathologies, including cancer, stroke, and osteoporosis. Here, we aim to analyze the influence of the TP53 Arg72Pro SNP on bone mass in humanized Tp53 Arg72Pro knock-in mice. This work reports on the influence of the TP53 Arg72Pro polymorphism in bone microarchitecture, OPG expression, and apoptosis bone s

SUBMITTER: Usategui-Martin R 

PROVIDER: S-EPMC10855390 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature