Efficacy of Enamel Matrix Derivative in Periodontal Regeneration Defects: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

To evaluate the efficacy of enamel matrix derivative (EMD) on periodontal regeneration defects.

Materials and methods

Four databases were searched until October 2021. Experimental animal studies evaluating the efficacy of EMD were used. The primary outcomes were bone formation (BF) and cementum formation (CF). The secondary outcomes were junctional epithelium (JE), gingival recession (GR), and clinical attachment level (CAL). Measures of effect were mean difference (MD) with 95% confidence intervals (CIs). Random-effects model were used for all meta-analyses. The Systematic Review Centre for Laboratory animal Experimentation tool was used to assess the risk of bias.

Results

Seven experimental animal studies (n = 40) used with a maximum follow-up period of 3

SUBMITTER: Mayta-Tovalino F 

PROVIDER: S-EPMC10855512 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature