New Insights into Endogenous Retrovirus-K Transcripts in Amyotrophic Lateral Sclerosis.

ABSTRACT: Retroviral reverse transcriptase activity and the increased expression of human endogenous retroviruses (HERVs) are associated with amyotrophic lateral sclerosis (ALS). We were interested in confirming HERVK overexpression in the ALS brain, its use as an accessory diagnostic marker for ALS, and its potential interplay with neuroinflammation. Using qPCR to analyze HERVK expression in peripheral blood mononuclear cells (PBMCs) and in postmortem brain samples from ALS patients, no significant differences were observed between patients and control subjects. By contrast, we report alterations in the expression patterns of specific HERVK copies, especially in the brainstem. Out of 27 HERVK copies sampled, the relative expression of 17 loci was >1.2-fold changed

SUBMITTER: Moreno-Martinez L 

PROVIDER: S-EPMC10855536 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature