Comparative Cyto-Histological Genetic Profile in a Series of Differentiated Thyroid Carcinomas.

ABSTRACT:

Introduction

Molecular tests can contribute to improve the preoperative diagnosis of thyroid nodules. Tests available are expensive and not adapted to different populations.

Aim

This study aimed to compare the cyto-histological genetic profile and to evaluate the reliability of molecular tests using ultrasound-guided fine needle aspiration cytology (US-FNAC) in accurately diagnosing differentiated thyroid carcinomas (DTCs) and predicting biologic behavior of papillary thyroid carcinomas (PTCs).

Materials and methods

The series included 259 patients with paired cyto-histological samples totaling 518 samples. The genetic alterations were analyzed via PCR/Sanger sequencing. The association with clinicopathologic features was evaluated in PTCs.

Results/discussion

F

SUBMITTER: Matos ML 

PROVIDER: S-EPMC10855767 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature