Alterations in Plasma Lipid Profiles Associated with Melanoma and Therapy Resistance.

ABSTRACT: Dysfunctions of lipid metabolism are associated with tumor progression and treatment resistance of cutaneous melanoma. BRAF/MEK inhibitor resistance is linked to alterations of melanoma lipid pathways. We evaluated whether a specific lipid pattern characterizes plasma from melanoma patients and their response to therapy. Plasma samples from patients and controls were analyzed for FASN and DHCR24 levels and lipidomic profiles. FASN and DHCR24 expression resulted in association with disease condition and related to plasma cholesterol and triglycerides in patients at different disease stages (n = 144) as compared to controls (n = 115). Untargeted lipidomics in plasma (n = 40) from advanced disease patients and controls revealed altered levels of different lipids, includin

SUBMITTER: Dei Cas M 

PROVIDER: S-EPMC10855791 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature