Mesenchymal Stem Cells from Familial Alzheimer's Patients Express MicroRNA Differently.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the predominant form of dementia globally. No reliable diagnostic, predictive techniques, or curative interventions are available. MicroRNAs (miRNAs) are vital to controlling gene expression, making them valuable biomarkers for diagnosis and prognosis. This study examines the transcriptome of olfactory ecto-mesenchymal stem cells (MSCs) derived from individuals with the PSEN1(A431E) mutation (Jalisco mutation). The aim is to determine whether this mutation affects the transcriptome and expression profile of miRNAs and their target genes at different stages of asymptomatic, presymptomatic, and symptomatic conditions. Expression microarrays compare the MSCs from mutation carriers with those from healthy donors. The resu

SUBMITTER: Rochin-Hernandez LJ 

PROVIDER: S-EPMC10855944 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature