Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments.

ABSTRACT: The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. Further, damage to the endothelium can be both a cause and a consequence of many diseases, especially in elderly people. The purpose of this study was to carry out immunological and biochemical profiling of elderly people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), and subcortical ischemic vascular dementia (SIVD). Socio-demographic, lifestyle, and cognitive data were obtained. Biochemical, hematological, and immunological analyses were carried out, and extracellular vesicles (EVs) with endothelial CD markers were assessed. The greatest number of significant devi

SUBMITTER: Goncharov NV 

PROVIDER: S-EPMC10855959 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature