Solvent- and Catalyst-Free Synthesis of gem-Difluorinated and Polyfluoroarylated Compounds with Nucleophilic or Electrophilic Fluorine-Containing Reaction Partners, Respectively.

ABSTRACT: A novel, efficient and environmentally friendly solvent-free and catalyst-free approach for the synthesis of structurally diverse gem-difluorinated and polyfluoroarylated derivatives with readily available nucleophilic and electrophilic fluorine-containing reaction partners, difluoroenoxysilane and pentafluorobenzaldehyde, is described. This neat protocol is induced by the direct hydrogen-bond interactions between fluorinated and non-fluorinated reactants without the use of heavy metal catalysts or volatile organic solvents and with no need for column chromatographic separation for most cases.

SUBMITTER: Li L 

PROVIDER: S-EPMC10856203 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature