The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring.

ABSTRACT: Background: Chorioamnionitis during labor exposes the fetus to an intrauterine state that may alter the future immune response and may expose the offspring to future susceptibility to infectious disease. We evaluated the long-term pediatric infectious morbidity of children born at term to mothers who have chorioamnionitis during labor. Methods: This was a population-based cohort analysis including only term singleton deliveries at a regional tertiary hospital between the years 1991 and 2021. Offspring to mothers with and without a diagnosis of chorioamnionitis during labor were compared. Offspring hospitalizations up to the age of 18 years involving infectious morbidity were evaluated using the Kaplan-Meier survival curve and a Cox regression model to control possible confoun

SUBMITTER: Davidi NE 

PROVIDER: S-EPMC10856245 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature