Identification and Validation of Magnolol Biosynthesis Genes in Magnolia officinalis.

ABSTRACT: Bacterial infections pose a significant risk to human health. Magnolol, derived from Magnolia officinalis, exhibits potent antibacterial properties. Synthetic biology offers a promising approach to manufacture such natural compounds. However, the plant-based biosynthesis of magnolol remains obscure, and the lack of identification of critical genes hampers its synthetic production. In this study, we have proposed a one-step conversion of magnolol from chavicol using laccase. After leveraging 20 transcriptomes from diverse parts of M. officinalis, transcripts were assembled, enriching genome annotation. Upon integrating this dataset with current genomic information, we could identify 30 laccase enzymes. From two potential gene clusters associated with magnolol production, highl

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10856379 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature