A Novel Quercetin Encapsulated Glucose Modified Liposome and Its Brain-Target Antioxidative Neuroprotection Effects.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC10856503 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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A Novel Quercetin Encapsulated Glucose Modified Liposome and Its Brain-Target Antioxidative Neuroprotection Effects.
Chen Jian J Chen Jinxia J Yu Peiyun P Yang Chunyan C Xia Chen C Deng Junlin J Yu Manyou M Xiang Zuoya Z Gan Lu L Zhu Boyu B Wu Yong Y Yang Xing X
Molecules (Basel, Switzerland) 20240126 3
Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized a novel glucose-modified QU liposome (QU-Glu-Lip), aiming not only to overcome QU's poor water solubility and bioavailability but also to deliver more QU to brain tissue to enhance its neuroprotective effect. QU-Glu-Lip possessed encapsulation efficiency (EE) of 89.9 ...[more]
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