Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children.

ABSTRACT:

Background

Molar incisor hypomineralization (MIH) is a qualitative, demarcated enamel defect of hypomineralization affecting one to four first permanent molars, often with incisor involvement. Its etiology is complex. However, evidence suggests the influence of genetic factors, potentially including the single nucleotide polymorphisms (SNPs) rs2889956, rs4811117 and rs13058467, which were previously linked to MIH in a genome-wide association study of German children. The aim was to replicate analyses of possible associations between the SNPs and molar incisor hypomineralization in Polish children.

Methods

The final study group consisted of 778 children aged 126-168 months old. Saliva samples were taken, and genomic DNA was extracted and genotyped using beadchip microarrays.<

SUBMITTER: Milona M 

PROVIDER: S-EPMC10856562 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature