Aminoquinoline-Based Tridentate (<i>NNN</i>)-Copper Catalyst for C-N Bond-Forming Reactions from Aniline and Diazo Compounds.

ABSTRACT: A new tridentate Cu²⁺ complex based on (E)-1-(pyridin-2-yl)-N-(quinolin-8-yl)methanimine (PQM) was generated and characterized to support the activation of diazo compounds for the formation of new C-N bonds. This neutral Schiff base ligand was structurally characterized to coordinate with copper(II) in an equatorial fashion, yielding a distorted octahedral complex. Upon characterization, this copper(II) complex was used to catalyze an efficient and cost-effective protocol for C-N bond formation between N-nucleophiles and copper carbene complexes arising from the activation of diazo carbonyl compounds. A substrate scope of approximately 15 different amine-based substrates was screened, yielding 2° or 3° amine products with acceptable to good yields under mild

SUBMITTER: Teimouri M 

PROVIDER: S-EPMC10856582 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature