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Prevention and Potential Treatment Strategies for Respiratory Syncytial Virus.

ABSTRACT: Respiratory syncytial virus (RSV) is a significant viral pathogen that causes respiratory infections in infants, the elderly, and immunocompromised individuals. RSV-related illnesses impose a substantial economic burden worldwide annually. The molecular structure, function, and in vivo interaction mechanisms of RSV have received more comprehensive attention in recent times, and significant progress has been made in developing inhibitors targeting various stages of the RSV replication cycle. These include fusion inhibitors, RSV polymerase inhibitors, and nucleoprotein inhibitors, as well as FDA-approved RSV prophylactic drugs palivizumab and nirsevimab. The research community is hopeful that these developments might provide easier access to knowledge and might spark new ideas for research programs.

SUBMITTER: Sun BW

PROVIDER: S-EPMC10856762 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Prevention and Potential Treatment Strategies for Respiratory Syncytial Virus.

Sun Bo-Wen BW Zhang Peng-Peng PP Wang Zong-Hao ZH Yao Xia X He Meng-Lan ML Bai Rui-Ting RT Che Hao H Lin Jing J Xie Tian T Hui Zi Z Ye Xiang-Yang XY Wang Li-Wei LW

Molecules (Basel, Switzerland) 20240125 3

Respiratory syncytial virus (RSV) is a significant viral pathogen that causes respiratory infections in infants, the elderly, and immunocompromised individuals. RSV-related illnesses impose a substantial economic burden worldwide annually. The molecular structure, function, and in vivo interaction mechanisms of RSV have received more comprehensive attention in recent times, and significant progress has been made in developing inhibitors targeting various stages of the RSV replication cycle. Thes ...[more]

PMID: 38338343

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