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Upconversion-Powered Photoelectrochemical Bioanalysis for DNA Sensing.

ABSTRACT: In this work, we report a new concept of upconversion-powered photoelectrochemical (PEC) bioanalysis. The proof-of-concept involves a PEC bionanosystem comprising a NaYF₄:Yb,Tm@NaYF₄ upconversion nanoparticles (UCNPs) reporter, which is confined by DNA hybridization on a CdS quantum dots (QDs)/indium tin oxide (ITO) photoelectrode. The CdS QD-modified ITO electrode was powered by upconversion absorption together with energy transfer effect through UCNPs for a stable photocurrent generation. By measuring the photocurrent change, the target DNA could be detected in a specific and sensitive way with a wide linear range from 10 pM to 1 μM and a low detection limit of 0.1 pM. This work exploited the use of UCNPs as signal reporters and realized upconversion-powered PEC bioanalysis. Given the diversity of UCNPs, we believe it will offer a new perspective for the development of advanced upconversion-powered PEC bioanalysis.

SUBMITTER: Liu H

PROVIDER: S-EPMC10856881 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Upconversion-Powered Photoelectrochemical Bioanalysis for DNA Sensing.

Liu Hong H Wei Weiwei W Song Jiajun J Hu Jin J Wang Zhezhe Z Lin Peng P

Sensors (Basel, Switzerland) 20240124 3

In this work, we report a new concept of upconversion-powered photoelectrochemical (PEC) bioanalysis. The proof-of-concept involves a PEC bionanosystem comprising a NaYF<sub>4</sub>:Yb,Tm@NaYF<sub>4</sub> upconversion nanoparticles (UCNPs) reporter, which is confined by DNA hybridization on a CdS quantum dots (QDs)/indium tin oxide (ITO) photoelectrode. The CdS QD-modified ITO electrode was powered by upconversion absorption together with energy transfer effect through UCNPs for a stable photocu ...[more]

PMID: 38339489

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