Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids.

ABSTRACT: Chagas disease and leishmaniasis are among the most widespread neglected tropical diseases, and their current therapies have limited efficacy and several toxic side effects. The present study reports the chemical and antikinetoplastid profiles of extracts from five Salvadoran Celastraceae species against the Trypanosoma cruzi epimastigotes stage and Leishmania amazonensis and Leishmania donovani promastigote forms. The phytochemical profile evinced the presence of flavonoids, tannins, sterols, and triterpenes as the main components in all plant species, whereas quinonemethide triterpenoids (QMTs) were restricted to the root bark of the studied species. Antikinetoplastid evaluation highlights the root bark extracts from Zinowewia integerrima, Maytenus segoviar

SUBMITTER: Nunez MJ 

PROVIDER: S-EPMC10857229 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature