Identification of abdominal aortic aneurysm subtypes based on mechanosensitive genes.

ABSTRACT:

Background

Rupture of abdominal aortic aneurysm (rAAA) is a fatal event in the elderly. Elevated blood pressure and weakening of vessel wall strength are major risk factors for this devastating event. This present study examined whether the expression profile of mechanosensitive genes correlates with the phenotype and outcome, thus, serving as a biomarker for AAA development.

Methods

In this study, we identified mechanosensitive genes involved in AAA development using general bioinformatics methods and machine learning with six human datasets publicly available from the GEO database. Differentially expressed mechanosensitive genes (DEMGs) in AAAs were identified by differential expression analysis. Molecular biological functions of genes were explored using functional cluste

SUBMITTER: Sheng C 

PROVIDER: S-EPMC10857568 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature