Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress.

ABSTRACT:

Background

Agomelatine (AGO) is an antidepressant with unique pharmacological effects; however, its underlying mechanisms remain unknown. In this study, we examined agomelatine's effects on catalase activity, oxidative stress, and inflammation.

Methods

Chronic restraint stress (CRS) model mice were established over 4 weeks, and AGO 50 mg/kg was administered to different groups alongside a deferasirox (DFX) 10 mg/kg gavage treatment. Behavioral tests were performed to assess the effect of AGO on the remission of depression-like behaviors. Meanwhile, the expression of CAT, the oxidative stress signaling pathway and inflammatory protein markers were assessed using ELISA, qRT-PCR, Western blot, and immunohistochemistry.

Results

Four weeks of AGO treatment significantly im

SUBMITTER: Xu J 

PROVIDER: S-EPMC10857580 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature