Association of Epigenetic Age and Outcome in Critically Ill Patients.

ABSTRACT:

Objectives

DNA methylation can be used to determine an individual's biological age, as opposed to chronological age, an indicator of underlying health status. This study aimed to assess epigenetic age in critically ill patients with and without sepsis to determine if higher epigenetic age is associated with admission diagnosis or mortality.

Design

Secondary analysis of whole blood DNA methylation data generated from a nested case-control study of critically ill septic and nonseptic patients.

Setting

Four tertiary care hospitals in Canada.

Interventions

None.

Patients

Critically ill patients with and without sepsis.

Measurements and main results

Epigenetic age was derived from DNA methylation data using the Hannum and PhenoAge algorithms and deviat

SUBMITTER: Sharma-Oates A 

PROVIDER: S-EPMC10857665 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature