Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma.

ABSTRACT: Apicomplexans are ubiquitous intracellular parasites of animals. These parasites use a programmed sequence of secretory events to find, invade, and then re-engineer their host cells to enable parasite growth and proliferation. The secretory organelles micronemes and rhoptries mediate the first steps of invasion. Both secrete their contents through the apical complex which provides an apical opening in the parasite's elaborate inner membrane complex (IMC) - an extensive subpellicular system of flattened membrane cisternae and proteinaceous meshwork that otherwise limits access of the cytoplasm to the plasma membrane for material exchange with the cell exterior. After invasion, a second secretion programme drives host cell remodelling and occurs from dense granules. The site(s) of dense gran

SUBMITTER: Chelaghma S 

PROVIDER: S-EPMC10857790 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature