Anal Canal Melanoma: Challenging the Odds.

ABSTRACT:

Introduction

Anal canal melanoma is a rare form of both anal cancer and skin melanoma, representing 1% of all anal cancers. Diagnosis is often made at an advanced disease stage. Because of late diagnosis and aggressive clinical course, anal canal melanoma has a very poor prognosis.

Case presentation

We present the case of a 61-year-old female with anal canal melanoma and lung, liver, pelvic and central nervous system (CNS) metastasis, BRAF V600E mutated. Combined BRAF/MEK inhibition and CNS radiation therapy were able to achieve excellent local and distant disease control.

Conclusion

Anal canal melanoma is a rare and aggressive form of melanoma. Multidisciplinary management in experienced centers is mandatory for good clinical outcomes.

SUBMITTER: Magno S 

PROVIDER: S-EPMC10857807 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature