Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy.

ABSTRACT:

Background

Biological sex has a diverse impact on the cardiovascular system. Its influence on dilated cardiomyopathy (DCM) remains unresolved.

Objectives

This study aims to investigate sex-specific differences in DCM presentation, natural history, and prognostic factors.

Methods

The authors conducted a prospective observational cohort study of DCM patients assessing baseline characteristics, cardiac magnetic resonance imaging, biomarkers, and genotype. The composite outcome was cardiovascular mortality or major heart failure (HF) events.

Results

Overall, 206 females and 398 males with DCM were followed for a median of 3.9 years. At baseline, female patients had higher left ventricular ejection fraction, smaller left ventricular volumes, less prevalent mid-wall

SUBMITTER: Owen R 

PROVIDER: S-EPMC10857810 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature