Combined Hepatocellular-Cholangiocarcinoma: Biology, Diagnosis, and Management.

ABSTRACT:

Background

Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.

Summary

Because of its aggressive nature, patients with cHCC-iCCA exhibit a poorer prognosis than those with HCC. Surgical resection and liver transplantation may be considered curative treatment approaches; however, only a minority of patients are eligible at the time of diagnosis, and postoperative recurrence rates are high. For cases that are not eligible for surgery, locoregional and systemic therapy are often administered based on treatment protocols applied for HCC or iCCA. Owing to the rarity of this cancer, there are still no established standard treatment protocols; therefore, the

SUBMITTER: Ye L 

PROVIDER: S-EPMC10857821 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature