Prognostic significance of liver stiffness in patients with primary biliary cholangitis: validation of Baveno VII criteria.

ABSTRACT:

Background

The role of liver stiffness measurements (LSM) in patients with primary biliary cholangitis (PBC) remains to be further elucidated.

Aims

To clarify the prognostic role of LSM and to validate the "novel concepts" proposed by the Baveno VII Working Group.

Methods

An analysis of the prognostic significance of LSM was performed involving 672 patients.

Results

LSM and ΔLSM/ΔT were independent risk factors for liver decompensation, liver transplantation, or liver-related death (primary outcomes, p < 0.001, both). A rule of 5 kPa for LSM (10-15-20 kPa) could be used to denote progressively higher relative risks of primary outcomes. Patients with LSM < 10 kPa have a negligible 3-year risk of primary outcomes (< 1%). Cut-off values of 10 and 15 kPa can be use

SUBMITTER: Ding D 

PROVIDER: S-EPMC10857967 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature