The association of stroke with herpes zoster ophthalmicus.

ABSTRACT:

Background/objectives

Studies have reported an association between herpes zoster ophthalmicus (HZO) and stroke. We sought to validate this association with rigorous controls for both medical comorbidities and social factors using a nationwide U.S. administrative medical claims database.

Subjects/methods

A two-step approach was taken: first a retrospective case-control study was performed, followed by a self-controlled case series (SCCS). For the case control study, cox proportional hazard regression with inverse proportional treatment weighting assessed the hazard for stroke. In the SCCS, incidence of stroke was compared prior to and after the diagnosis of HZO.

Results

For the case-control study, 25,720 cases and 75,924 controls met our eligibility criteria. 1712 (6.7

SUBMITTER: Gupta AS 

PROVIDER: S-EPMC10858032 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature