Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics.

ABSTRACT: Microfabricated organ-on-a-chips are rapidly becoming the gold standard for the testing of safety and efficacy of therapeutics. A broad range of designs has emerged, but recreating microvascularised tissue models remains difficult in many cases. This is particularly relevant to mimic the systemic delivery of therapeutics, to capture the complex multi-step processes associated with trans-endothelial transport or diffusion, uptake by targeted tissues and associated metabolic response. In this report, we describe the formation of microvascularised cardiac spheroids embedded in microfluidic chips. Different protocols used for embedding spheroids within vascularised multi-compartment microfluidic chips were investigated first to identify the importance of the spheroid processing, and co-culture

SUBMITTER: Di Cio S 

PROVIDER: S-EPMC10858047 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature