Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study.

ABSTRACT:

Background

There is growing recognition of natural history, complications, and outcomes of patients who develop non-acetaminophen (APAP) drug-induced acute liver failure (ALF). To clarify high-risk factors and develop a nomogram model to predict transplant-free survival (TFS) in patients with non-APAP drug-induced ALF.

Methods

Patients with non-APAP drug-induced ALF from 5 participating centers were retrospectively analyzed. The primary endpoint was 21-day TFS. Total sample size was 482 patients.

Results

Regarding causative agents, the most common implicated drugs were herbal and dietary supplements (HDS) (57.0%). The hepatocellular type (R ≥ 5) was the main liver injury pattern (69.0%). International normalized ratio, hepatic encephalopathy grades, the use of vasopre

SUBMITTER: Han L 

PROVIDER: S-EPMC10858105 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature