Individual variations in motives for nicotine self-administration in male rats: evidence in support for a precision psychopharmacology.

ABSTRACT: The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved smoking cessation therapies, supports the presence of individual variations in the mechanisms underlying smoking. This emphasizes the need to shift from standardized to personalized smoking cessation therapies. However, informed precision medicine demands precision fundamental research. Tobacco smoking is influenced and sustained by diverse psychopharmacological interactions between nicotine and environmental stimuli. In the classical experimental rodent model for studying tobacco dependence, namely intravenous self-administration of nicotine, seeking behavior is reinforced by the combined delivery of nicotine and a discrete cue (nicotine+cue). Whether self-administration beh

SUBMITTER: Garcia-Rivas V 

PROVIDER: S-EPMC10858238 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature