Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration.

ABSTRACT: Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction, and this leads to various clinical complications including diabetic foot ulcers. The vascular endothelial cells, which compactly line the inner surface of blood vessels, are responsible for the growth and maintenance of blood vessels and play an essential role in tissue regeneration. Although the mechanical properties of cells are generally known to be regulated by physiological/pathological conditions, few studies have been performed to investigate vascular endothelial cellular mechanics under hyperglycemia and the biological functions related to tissue regeneration. In this study, we conduct a systematic investigation o

SUBMITTER: Wang K 

PROVIDER: S-EPMC10858347 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature