Large airway T cells in adults with former bronchopulmonary dysplasia.

ABSTRACT:

Background

Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown.

Objective

To characterize cellular and T cell profiles in the large airways of young adults with a history of BPD.

Methods

Forty-three young adults born prematurely (preterm (n = 20), BPD (n = 23)) and 45 full-term-born (asthma (n = 23), healthy (n = 22)) underwent lung function measurements, and bronchoscopy with large airway bronchial wash (BW). T-cells subsets in BW were analyzed by immunocytochemistry.

Results

The proportions of both lymphocytes and CD8 + T cells in BW were significantly higher in BPD (median, 6.6%, and 78.0%) when compared with ast

SUBMITTER: Gao J 

PROVIDER: S-EPMC10858477 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature