The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear.

Methods

In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV₁ and lung diffusing capacity (D_LCOc and D_LCOc /alveolar volume [V_A]) were measured. Associations of SAF with asthma, COPD, GOLD stage, and lung function were analyzed using logistic and linear regression adjusted for covariates, followed by interaction and stratification analyses. sRAGE and EN-RAGE associations with COPD prevalence were analyzed by logistic regression.

Results

SAF ass

SUBMITTER: Lu T 

PROVIDER: S-EPMC10858545 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature