Dataset Information

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear.

Methods

In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV₁ and lung diffusing capacity (D_LCOc and D_LCOc /alveolar volume [V_A]) were measured. Associations of SAF with asthma, COPD, GOLD stage, and lung function were analyzed using logistic and linear regression adjusted for covariates, followed by interaction and stratification analyses. sRAGE and EN-RAGE associations with COPD prevalence were analyzed by logistic regression.

Results

SAF associated with COPD prevalence (OR = 1.299 [1.060, 1.591]) but not when adjusted for smoking (OR = 1.106 [0.89, 1.363]). SAF associated with FEV₁% predicted (β=-3.384 [-4.877, -1.892]), D_LCOc (β=-0.212 [-0.327, -0.097]) and GOLD stage (OR = 4.073, p = 0.001, stage 3&4 versus 1). Stratified, the association between SAF and FEV₁%predicted was stronger in COPD (β=-6.362 [-9.055, -3.670]) than non-COPD (β=-1.712 [-3.306, -0.118]). Association of SAF with D_LCOc and D_LCOc/V_A were confined to COPD (β=-0.550 [-0.909, -0.191]; β=-0.065 [-0.117, -0.014] respectively). SAF interacted with former smoking and COPD prevalence for associations with lung function. Lower sRAGE and higher EN-RAGE associated with COPD prevalence (OR = 0.575[0.354, 0.931]; OR = 1.778[1.142, 2.768], respectively).

Conclusions

Associations between SAF, lung function and COPD prevalence were strongly influenced by smoking. SAF associated with COPD severity and its association with lung function was more prominent within COPD. These results fuel further research into interrelations and causality between SAF, smoking and COPD.

Take-home message

Skin AGEs associated with prevalence and severity of COPD and lung function in the general population with a stronger effect in COPD, calling for further research into interrelations and causality between SAF, smoking and COPD.

SUBMITTER: Lu T

PROVIDER: S-EPMC10858545 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

Lu Tianqi T Lahousse Lies L Wijnant Sara S Chen Jinluan J Brusselle Guy G GG van Hoek Mandy M Zillikens M Carola MC

Respiratory research 20240209 1

<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear.<h4>Methods</h4>In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV<sub>1</sub> and lung diffusing capacity (D<sub>LCO</sub>c and D<sub>LCO</sub>c /alveolar volume [V<sub>A</sub>]) were measured. Associatio ...[more]

PMID: 38336742

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Dataset Information

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

Background

Methods

Results

Conclusions

Take-home message

Publications

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

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