Non-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures.

ABSTRACT:

Introduction

Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important to find out whether cancer cells can proliferate independent of mitosis and become resistant to anti-mitotic agents.

Results

In this study, live-cell imaging was applied to both primary-cultures of tumor cells, and immortalized cancer cell lines, to detect aberrant proliferations. Cells isolated from various malignant tumors, such as Grade-III hemangiopericytoma, atypical meningioma, and metastatic brain tumor exhibit distinct cellular behaviors, including amoeboid sequestration, tailing, tunneling, nucleic DNA leakage, as w

SUBMITTER: Tyagi IS 

PROVIDER: S-EPMC10858565 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature