Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans.

ABSTRACT:

Aim

Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related therapies. We aimed to identify regulators of diabetic myocardial ischemic injury.

Methods and results

Mass spectrometry-based, non-targeted metabolomic approach was used to profile coronary sinus blood from diabetic and non-diabetic Bama-mini pigs at 0.5-h post coronary artery ligation. Six metabolites had a |log₂ (Fold Change)|> 1.3. Among them, the most changed is arachidonic acid (AA), levels of which were 32 times lower in diabetic pigs than in non-diabetic pigs. The AA-derived products, PGI₂ and 6-keto-PGF_1α, were also significantly reduced. AA treatment of cultured cardiomyocytes protected

SUBMITTER: Lv Y 

PROVIDER: S-EPMC10858581 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature