Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.

ABSTRACT:

Rationale

Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described in several brain disorders, and genetically induced pericyte deficiency in the brain leads to increased macromolecular leakage across the blood-brain barrier (BBB). However, the molecular details of the endothelial response to pericyte deficiency remain elusive.

Objective

To map the transcriptional changes in brain endothelial cells resulting from lack of pericyte contact at single-cell level and to correlate them with regional heterogeneities in BBB function and vascular phenotype.

Methods and results

We reveal transcriptional, morphological, and functional consequences of pericyte absence fo

SUBMITTER: Mae MA 

PROVIDER: S-EPMC10858745 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature