Relaxed fibronectin: a potential novel target for imaging endometriotic lesions.

ABSTRACT:

Background

Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extracellular matrix. One major clinical hurdle concerning endometriosis is its diagnosis. The diagnostic modalities ultrasound and MRI are often unable to detect all lesions, and a clear correlation between imaging and clinical symptoms is still controversial. Therefore, it was our aim to identify a potential target to image active endometriotic lesions.

Results

For our studies, we employed the preclinical radiotracer [¹¹¹In]In-FnBPA5, which specifically binds to relaxed fibronectin-an extracellular matrix protein with key functions in homeostasis that

SUBMITTER: Trachsel B 

PROVIDER: S-EPMC10858858 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature