NF1 mutations as biomarker of response to immune checkpoint blockades for lung adenocarcinoma patients.
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ABSTRACT:
SUBMITTER: Giraud JS
PROVIDER: S-EPMC10858913 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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NF1 mutations as biomarker of response to immune checkpoint blockades for lung adenocarcinoma patients.
Giraud Jean-Stéphane JS Jouinot Anne A Pasmant Eric E Tlemsani Camille C
NPJ precision oncology 20240210 1
Little is known about immune checkpoint inhibitors (ICI) response of NF1-mutated lung adenocarcinomas. 341/4,181 (8.2%) TCGA lung adenocarcinomas samples have a somatic NF1 mutation. NF1-mutated tumors have higher TMB (p < 0.0001), higher expression of immune genes ("hot phenotype") and higher CD8 + T cell (p = 0.03) and macrophage (p = 0.02) infiltrations compared to NF1 wild-type tumors. NF1 mutation status appears as a candidate predictive biomarker for ICI response in lung adenocarcinoma pat ...[more]
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