Association study of the complement component C4 gene and suicide risk in schizophrenia.

ABSTRACT: Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10% dying from suicide. Although genetic components play a significant role in schizophrenia risk, the underlying genetic risk factors for suicide are poorly understood. The complement component C4 gene, an immune gene involved in the innate immune system and located in the major histocompatibility complex (MHC) region, has been identified to be strongly associated with schizophrenia risk. In addition, recent findings have also suggested that the MHC region has been associated with suicide risk across disorders, making C4 a potential candidate of interest for studying suicidality in schizophrenia patients. Despite growing interest in investigating th

SUBMITTER: Ebrahimi M 

PROVIDER: S-EPMC10858919 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature