PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies.

ABSTRACT:

Background

Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor (VEGF) targets the core pathology of ocular angiogenesis.

Main body

In recent years, therapies targeting metabolism to prevent angiogenesis have also rapidly developed, offering assistance to patients with a poor prognosis while receiving anti-VEGF therapy and reducing the side effects associated

SUBMITTER: Liu P 

PROVIDER: S-EPMC10859025 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature