A cuproptosis score model and prognostic score model can evaluate clinical characteristics and immune microenvironment in NSCLC.

ABSTRACT:

Background

Cuproptosis-related genes (CRGs) are associated with lung adenocarcinoma. However, the links between CRGs and non-small-cell lung cancer (NSCLC) are not clear. In this study, we aimed to develop two cuproptosis models and investigate their correlation with NSCLC in terms of clinical features and tumor microenvironment.

Methods

CRG expression profiles and clinical data from NSCLC and normal tissues was obtained from GEO (GSE42127) and TCGA datasets. Molecular clusters were classified into three patterns based on CRGs and cuproptosis cluster-related specific differentially expressed genes (CRDEGs). Then, two clinical models were established. First, a prognostic score model based on CRDEGs was established using univariate/multivariate Cox analysis. Then, through prin

SUBMITTER: Tang Y 

PROVIDER: S-EPMC10859031 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature