Prognostic Significance of Dual-Specificity Phosphatase 23 Expression in Acute Myeloid Leukemia.

ABSTRACT:

Background

Recently, an increasing number of studies have suggested dual-specificity phosphatase 23 (DUSP23) is a critical factor in the development of diffuse connective tissue disease and may be a valuable biomarker for primary human cancers. However, there is a lack of comprehensive studies on the prognostic significance of DUSP23 expression in acute myeloid leukemia (AML).

Methods

RNA sequencing data from The Cancer Genome Atlas (TCGA) (AML = 173), Genotype-Tissue Expression (GTEx) (healthy controls = 70) and GEO (AML = 461, healthy controls = 76) databases were used to compare DUSP23 expression between AML patients and healthy controls. The overall survival (OS) of DUSP23 in AML was evaluated using Kaplan-Meier Cox regression. Furthermore, univariate Cox regression and

SUBMITTER: Liu X 

PROVIDER: S-EPMC10859056 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature