Hyperglycaemia is a causal risk factor for upper limb pathologies.

ABSTRACT:

Background

Diabetes (regardless of type) and obesity are associated with a range of musculoskeletal disorders. The causal mechanisms driving these associations are unknown for many upper limb pathologies. We used genetic techniques to test the causal link between glycemia, obesity and musculoskeletal conditions.

Methods

In the UK Biobank's unrelated European cohort (N = 379 708) we performed mendelian randomisation (MR) analyses to test for a causal effect of long-term high glycaemia and adiposity on four musculoskeletal pathologies: frozen shoulder, Dupuytren's disease, carpal tunnel syndrome and trigger finger. We also performed single-gene MR using rare variants in the GCK gene.

Results

Using MR, we found evidence that long-term high glycaemia has a causal role in

SUBMITTER: Green HD 

PROVIDER: S-EPMC10859137 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature