Photonic control of ligand nanospacing in self-assembly regulates stem cell fate.

ABSTRACT: Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo⁺ self-assembly composed of azobenzene derivatives (Azo⁺) stacked via cation-π interactions and stabilized with RGD ligand-bearing poly(acrylic acid). Near-infrared-upconverted-ultraviolet light induces cis-Azo⁺-mediated inflation that suppresses cation-π interactions, thereby inflating liganded self-assembly. This inflation increases nanospacing of "closely nanospaced" ligands from 1.8 nm to 2.6 nm and the surface area of liganded self-assembly that facilitate stem cell adhesion, mechanosensing, and differentiation both in vitro and in vi

SUBMITTER: Lee S 

PROVIDER: S-EPMC10859239 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature