Osseous implications of proton pump inhibitor therapy: An umbrella review.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide for acid-related disorders. While their short-term efficacy and safety are well-established, concerns regarding their long-term effects on bone health have emerged. This umbrella review aimed to synthesize the available findings on the associations between PPI use and bone metabolism outcomes.

Methods

An electronic search was conducted using PubMed, Web of Science, Embase, and the Cochrane Database up to September 16, 2023. Systematic reviews and meta-analyses of randomized controlled trials (RCTs) and observational studies that evaluated the relationship between PPIs and bone metabolism outcomes were included. Data extraction, quality appraisal, and synthesis were performed

SUBMITTER: Alanazi AS 

PROVIDER: S-EPMC10859261 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature