Washed microbiota transplantation reduces glycemic variability in unstable diabetes.

ABSTRACT:

Background

Dysbiosis of gut microbiota is causally linked to impaired host glucose metabolism. We aimed to study effects of the new method of fecal microbiota transplantation, washed microbiota transplantation (WMT), on reducing glycemic variability (GV) in unstable diabetes.

Methods

Fourteen eligible patients received three allogenic WMTs and were followed up at 1 week, 1 month, and 3 months. Primary outcomes were daily insulin dose, glucose excursions during meal tests, and GV indices calculated from continuous monitoring or self-monitoring glucose values. Secondary outcomes were multiomics data, including 16S rRNA gene sequencing, metagenomics, and metabolomics to explore underlying mechanisms.

Results

Daily insulin dose and glucose excursions markedly dropped, whe

SUBMITTER: Li Y 

PROVIDER: S-EPMC10859319 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature