Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study.

ABSTRACT:

Purpose

Preliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyzed bone metabolism in a sample of transgender adults before GAHT, and its possible correlation with biochemical profile, body composition and lifestyle habits (i.e., tobacco smoke and physical activity).

Methods

Medical data, smoking habits, phospho-calcic and hormonal blood tests and densitometric parameters were collected in a sample of 125 transgender adults, 78 Assigned Females At Birth (AFAB) and 47 Assigned Males At Birth (AMAB) before GAHT initiation and 146 cisgender controls (57 females and 89 males) matched by sex assigned at birth and age. 55 transgen

SUBMITTER: Ceolin C 

PROVIDER: S-EPMC10859333 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature