FOXM1 promote the growth and metastasis of uveal melanoma cells by regulating CDK2 expression.

ABSTRACT:

Background

Uveal melanoma (UVM) is an aggressive malignant tumor originating from melanocytes in the eye. Here, we screened the possible genes involved in the development and prognosis of UVM, and identified that FOXM1 and MET were associated with the prognosis of UVM patients. Forkhead box protein M1 (FOXM1) is a transcription factor that regulates the expression of cell cycle-related genes that are necessary for DNA duplication. However, the regulatory mechanism of FOXM1 in UVM was still not clear. Here, we investigated the regulation of FOXM1 in the malignant phenotype of UVM cells and its effect on the prognosis of UVM patients.

Methods

UVM gene expression profiles were obtained using GSE22138 data from the gene expression omnibus (GEO). Weighted gene co-expression netwo

SUBMITTER: Bai X 

PROVIDER: S-EPMC10859341 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature