Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo.

ABSTRACT: The incidence of life-threatening ventricular arrhythmias, the most common cause of sudden cardiac death (SCD), depends largely on the arrhythmic substrate that develops in the myocardium during the aging process. There is a large deficit of comparative studies on the development of this substrate in both sexes, with a particular paucity of studies in females. To identify the substrates of arrhythmia, fibrosis, cardiomyocyte hypertrophy, mitochondrial density, oxidative stress, antioxidant defense and intracellular Ca²⁺ signaling in isolated cardiomyocytes were measured in the hearts of 3- and 24-month-old female and male rats. Arrhythmia susceptibility was assessed in ex vivo perfused hearts after exposure to isoproterenol (ISO) and hydrogen peroxide (H₂O₂

SUBMITTER: Okninska M 

PROVIDER: S-EPMC10859380 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature