Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults.

ABSTRACT: The central nervous system encounters a number of challenges following HIV infection, leading to increased risk for a collection of neurocognitive symptoms clinically classified as HIV-associated neurocognitive disorders (HAND). Studies attempting to identify causal mechanisms and potential therapeutic interventions have historically relied on primary rodent neurons, but a number of recent reports take advantage of iPSC-derived neurons in order to study these mechanisms in a readily reproducible, human model. We found that iPSC-derived neurons differentiated via an inducible neurogenin-2 transcription factor were resistant to gross toxicity from a number of HIV-associated insults previously reported to be toxic in rodent models, including HIV-infected myeloid cell supernatants and the inte

SUBMITTER: Starr A 

PROVIDER: S-EPMC10859444 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature